March 2024
Publication:
Reduced slow wave density is associated with worse positive symptoms in clinical high risk: An objective readout of symptom severity for early treatment interventions?
An article about an HD-EEG study looking at positive symptoms in clinical high risk participants and a healthy control group. Read here: https://pubmed.ncbi.nlm.nih.gov/38281453/
February 2024
Publication:
Changes in electroencephalographic microstates between evening and morning are associated with overnight sleep slow waves in healthy individuals
Microstates are electroencephalogram (EEG) voltage topographies, usually described as A, B, C, and D, that exhibit distinct characteristics and account for most of the variance observed in the EEG activity. Microstates are thought to represent stable neural traits with high test–retest reliability; however, the effects of time of the day and sleep on microstates have not been examined. Our study demonstrated evening to morning significant increases in microstate C characteristics that were inversely correlated to slow wave density. These findings suggest that sleep slow waves are implicated in the regulation of some microstate characteristics and that future microstate studies should control for time of the day and sleep effects. Read here: https://doi.org/10.1093/sleep/zsae053
April 22, 2023
Publication:
N-Acetylaspartate and Choline Metabolites in Cortical and Subcortical Regions in Clinical High Risk Relative to Healthy Control Subjects: An Exploratory 7T MRSI Study
An article about a 7T MRSI study looking at metabolic differences between clinical high risk participants and a healthy control group. Read here: https://www.mdpi.com/1422-0067/24/9/7682
April 14, 2023
Publication:
Shared and distinct abnormalities in sleep-wake patterns and their relationship with the negative symptoms of Schizophrenia Spectrum Disorder patients
An article about alterations in RAR and negative symptoms in schizophrenia spectrum disorder patients. Read here: https://www.nature.com/articles/s41380-023-02050-x
March 24, 2023
Publication:
Natural Oscillatory Frequency Slowing in the Premotor Cortex of Early-Course Schizophrenia Patients: A TMS-EEG Study
An article about a TMS- EEG study examining oscilatory patterns in the premotor cortex of patients with early course schizophrenia. Read here: https://www.mdpi.com/2076-3425/13/4/534
March 18, 2023
Podcast: Looking at Mental Disorders|How is the Brain Affected by Schizophrenia?
Dr. Ferrarelli was featured in a podcast! Listen here: https://open.spotify.com/episode/6Yi25Y2shhUSEUT3Vh0WQU
January 18, 2023
Publication: Sleep Abnormalities in Different Clinical Stages of Psychosis: A Systematic Review and Meta-analysis
A meta-analysis/systematic review on sleep abnormalities in different clinical stages of psychosis was published. Read here: https://pubmed.ncbi.nlm.nih.gov/36652243/
December 13, 2022
Publication: Dorsolateral Prefrontal Cortex Glutamate/Gamma-Aminobutyric Acid (GABA) Alterations in Clinical High Risk and First-Episode Schizophrenia: A Preliminary 7-T Magnetic Resonance Spectroscopy Imaging Study
An article about a 7T imaging study on glutamate/GABA in the DLPFC in clinical high risk and first episode schizophrenia was released. Read here: https://pubmed.ncbi.nlm.nih.gov/36555487/
December 2022
Poster: TMS Doses Based on Motor Threshold Differ Between DLPFC, OFC, and Motor Cortex: Electric Field Dosimetry Introduction Results
A poster about TMS doses based on motor threshold for different brain regions has been published. Read here: https://www.researchgate.net/publication/366158154_TMS_Doses_Based_on_Motor_Threshold_Differ_Between_DLPFC_OFC_and_Motor_Cortex_Electric_Field_Dosimetry_Introduction_Results
November 9, 2022
Publication: Sleep spindle alterations relate to working memory deficits in individuals at clinical high-risk for psychosis
An article about sleep spindle alterations in individuals at clinical high-risk for psychosis was published. Read here: https://pubmed.ncbi.nlm.nih.gov/35981865/
November 4, 2022
Publication: Bayesian Optimization of Machine Learning Classification of Resting-State EEG Microstates in Schizophrenia: A Proof-of-Concept Preliminary Study Based on Secondary Analysis
An article on using Bayesian optimization of Machine Learning to characterize EEG microstate alterations in schizophrenia was published. Read here: https://pubmed.ncbi.nlm.nih.gov/36358423/
November 2022
Publication: A narrative review of treatment interventions to improve cognitive performance in schizophrenia, with an emphasis on at-risk and early course stages
A review on cognitive interventions in schizophrenia patients was published. Read here: https://www.sciencedirect.com/science/article/abs/pii/S0165178122005170
September 19, 2022
Publication: Relationships between rest-activity rhythms, sleep, and clinical symptoms in individuals at clinical high risk for psychosis and healthy comparison subjects
An article discussing sleep-wake disturbances in individuals at clinical high-risk (CHR) of psychosis was published. Read here: https://pubmed.ncbi.nlm.nih.gov/36183600/
July 2022
Publication: Is Neuroplasticity Key to Treatment Response in Depression? Maybe So
An article on neuroplasticity and depression was published. Read here: https://pubmed.ncbi.nlm.nih.gov/35775160/
May 1, 2022
Publication: TMS Doses Based on Motor Threshold Differ Between DLPFC, OFC, and Motor Cortex: A Case for Electric Field Dosimetry in Clinical Studies
An article on the dosage of transcranial magnetic stimulation on varying regions was published. Read here: https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)00282-7/fulltext
February 14, 2022
Publication: A trait of mind: stability and robustness of sleep across sleep opportunity manipulations during simulated military operational stress
An article on the trait-like behavior of sleep parameters was published. Read here: https://pubmed.ncbi.nlm.nih.gov/34432067/
February 8, 2022
Publication: First Night Effect on Sleep Parameters with hd-EEG in Healthy Individuals
An article about the First Night Effect as observed in hd-EEG data of healthy individuals was published. Read here: https://pubmed.ncbi.nlm.nih.gov/35203996/
September 7, 2021
New lab funding!
Our research lab was funded!! The proposal entitled: “Enhancing prefrontal oscillatory activity and working memory (WM) performance with noninvasive brain stimulation in early-course schizophrenia (Ferrarelli, PI) was funded (R01MH125816). In this project, we will use theta burst stimulation (TBS) over the left dorsolateral prefrontal cortex (DLPFC) in adults with early course schizophrenia (EC-SCZ) to: 1) establish the acute effects of active vs. sham TBS on DLPFC oscillatory activity of EC-SCZ patients.; 2) assess the impact of acute active vs. sham TBS on WM performance in EC-SCZ patients; and 3) Examine the relationship between TBS changes in DLPFC oscillatory activity and WM performance in EC-SCZ patients.
June 12, 2021
Publication: Reduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis
An article about observations the correlation between trends with transcranial magnetic stimulations and positive symptoms was published. Read here: https://pubmed.ncbi.nlm.nih.gov/34129889/ /
March 17, 2021
New Article: Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps
An article written by Dr. Ferrarelli about sleep abnormalities in schizophrenia was just published. Read here: https://pubmed.ncbi.nlm.nih.gov/33726524/
March 8, 2021
New Article: Sleep abnormalities in individuals at clinical high risk for psychosis
A new article regarding sleep abnormalities in individuals at clinical high risk for psychosis was just posted. Read here: https://pubmed.ncbi.nlm.nih.gov/33744512/
March 3, 2021
New Article: Examining and Modulating Neural Circuits in Psychiatric Disorders With Transcranial Magnetic Stimulation and Electroencephalography: Present Practices and Future Developments
A new article is up! Read here: https://pubmed.ncbi.nlm.nih.gov/33653120/
December 3, 2020
New Article: Reduced GABA/glutamate in the thalamus of individuals at clinical high risk for psychosis
We had an article entitled “Reduced GABA/glutamate in the thalamus of individuals at clinical high risk for psychosis” recently accepted in Neuropsychopharmacology (NPP). Gonzalo Quinones and Ahmad Mayeli lead the effort. To know more, please click on this link: https://www.nature.com/articles/s41386-020-00920-4.
December 1, 2020
Lab is funded to study theta burst stimulation (TBS) over vIPFC
We got funded!! Our proposal entitled: “Elucidating neural mechanisms of hypo/mania using theta burst stimulation (Ferrarelli, Phillips MPI) was funded (R01MH122990). In this project, we will use theta burst stimulation (TBS) over the left ventrolateral prefrontal cortex (vlPFC) in adults with bipolar disorder (BD) and a comparison group of non BD adults to: 1) determine the impact of TBS on left vlPFC and related brain circuitry activity and functional connectivity during reward anticipation; 2) assess whether TBS-induced brain changes lead to acute changes in hypo/mania-related affect, and how negative urgency influences these TBS-induced changes in brain and affect measures; and 3) compare the impact of TBS on these brain and affect measures in adults with BD and non BD adults.
May 16, 2019
Lab receives NIMH funding to study prefrontal oscillatory dysfunctions in early course SCZ
The PyNeL lab has been notified that NIMH will be funding their new TMS/hd-EEG study of early-course schizophrenia, NORDECS. Please refer to the “Current Studies” tab for more details.
March 1, 2019
Article interview: Expert Perspective: Treating Insomnia in Patients With Schizophrenia
March 1, 2019
New Article: An increase in sleep slow waves predicts better working memory performance in healthy individual
Ferrarelli F, Kaskie R, Laxminarayan S, Ramakrishnan S, Reifman J, Germain A
Neuroimage. 2019 Feb 10;191:1-9. doi: 10.1016/j.neuroimage.2019.02.020
December 27, 2018
New Article: Abnormalities in the evoked frontal oscillatory activity of first-episode psychosis: A TMS/EEG study
Fabio Ferrarelli , Rachel E. Kaskie, Bianca Graziano, Catarina Cardoso Reis, Adenauer G. Casali
Schizophr Res. 2018 Nov 22. pii: S0920-9964(18)30638-8
https://www.sciencedirect.com/science/article/pii/S0920996418306388?via%3Dihub
November 6, 2018
New Article: Reduced Frontal Slow Wave Density During Sleep In First-episode Psychosis
Rachel E. Kaskie, Kathryn M. Gill, Fabio Ferrarelli
Schizophr Res. 2018 Oct 27. pii: S0920-9964(18)30626-1
September 7, 2018
Psychiatry Advisor interviewed Fabio Ferrarelli, MD, PhD, and Lisa B. Dixon, MD, MPH, to discuss the implications of the Recovery After an Initial Schizophrenia Episode (RAISE) project. The purpose of this NIMH-funded project was to develop and test a coordinated specialty care (CSC) intervention for patients with early psychosis. It specifically investigated the effectiveness of NAVIGATE, a CAC approach that consisted of 4 manual-based interventions: psychopharmacology using a computerized decision support system (COMPASS), individual resilience therapy, family therapy and psychoeducation, and supportive employment and education.